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282,283 On the other hand, high ROS levels have been reported to induce apoptosis and surmount TKI resistance, as when exposed to excessive ROS, ASK1 potentiation results in the initiation of JNK and p38 MAPK and the induction of apoptosis

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This analytical gap has encouraged us to develop a new analytical protocol based on HPLC technique and UV detection to control the concentration of N-Hcy-Lys and related aminothiols, such as Cys, GSH and Hcy in human plasma